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Dataset Description

Dataset: CTCF ChIP-chip sites (Ren lab) (OREGDS00008) Description: Sites of CTCF binding in the human genome were located using ChIP-chip analysis. This involved the immunoprecipitation of CTCF bound DNA from formaldehyde-crosslinked cells, followed by detection with genome-tiling arrays, using a sample of chromatin from primary human fibroblast, IMR90 cells. A high-resolution map of CTCF-binding sites in the human genome with unique distribution and sequence features was generated. This map not only confirmed most known insulators and CTCF-binding sites but also identified over 13,000 novel CTCF-binding sequences and potential insulators. Nearly 80% of the CTCF-binding sites share a consensus motif that is highly conserved during evolution. It is also showed that CTCF-binding sites are largely invariant between cell types. Dataset URL: http://licr-renlab.ucsd.edu/download.html Citation Information: Kim TH, Abdullaev ZK, Smith AD, Ching KA, Loukinov DI, Green RD, Zhang MQ, Lobanenkov VV, Ren B. 2007. Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome. Cell. 128:1231-45. Citation URL: http://dx.doi.org/10.1016/j.cell.2006.12.048

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